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KMID : 0854720070270030157
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 3 p.157 ~ p.161
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Adverse Reactions to Radio-Contrast Media in Computed Tomography(CT) in General Population : Incidence and Clinical Features
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Kim Sun-Sin
Park Heung-Woo
Chang Yoon-Seok
Min Kyung-Up
Kim You-Young
Park Chang-Han
Park Min-Jeoung
Choi Seung-Ho
Shin Chan-Soo
Cho Sang-Heon
Oh Byung-Hee
Kim Young-Sun
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Abstract
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Background: Adverse reactions to radio-contrast media (CM) represent a serious problem. There have been few reports about incidence of adverse reactions to CM in general population.
Objective: The purpose of this study was to evaluate the incidence and clinical features of adverse reactions to low osmolar, nonionic contrast media in the general population.
Method: A total of 12,177 examinee underwent contrast-enhanced CT using low osmolar, nonionic CM. Immediate adverse reaction is defined as symptoms occur within 1 hour after contrast administration and late adverse reaction is defined as symptoms occur more than 1 hour but less than 7 days following contrast administration. A questio-nnaire was used to collect general and medical information.
Result: Adverse events were noted in 306 cases of total 13,552 cases. The incidence of adverse reactions was 2.3% and severe reactions was 0.04%. The incidence of immediate reaction was 2.0% and late reactions was 0.3%. Symptoms of immediate and late reactions were nausea/vomiting (22.2%), erythema/pruritus/urticaria (74.2%), angioedema (2.0%) and hypotension (1.6%).
Conclusion: The incidence of adverse reaction to low osmolar, nonionic CM was 2.3% in the general population. The skin was the most commonly affected site of adverse reactions.
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KEYWORD
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Contrast media, Adverse reactions, Incidence
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